JDRF supported research discovered active insulin-producing cells in people with type-1 Diabetes after 50 years with the disease.
Source: Diabetes, November 2010 issue reported results from the Joslin Medalist Study for which JDRF provided support. Here is the link;Residual Insulin Production and Pancreatic Beta Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study
CONCLUSIONS Demonstration of persistence and function of insulin-producing pancreatic cells suggests the possibility of a steady state of turnover in which stimuli to enhance endogenous beta cells could be a viable therapeutic approach in a significant number of patients, even for those with chronic duration.
JDRF support discovered that insulin-producing cells can replace themselves.
Source: This advance is reported in the JDRF FY10 Annual Report as Researchers discover that adult insulin-producing beta cells have the ability to successfully replicate, leading to new strategies in the field of regeneration.
The presence of progenitor cells in the pancreas suggests that strategies to form new beta cells can be developed.
Gastrin-based therapies are shown to promote regeneration in animal models; they are entering clinical trials
New insights into mechanisms underlying beta cell expansion during pregnancy and other physiologic conditions lead to new targets for drug discovery.
Reprogramming of alternative cell types to become functional beta cells opens up new avenues for beta cell regeneration.
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